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For these reasons, individuals with kidney disease (with or without the need for hemodialysis) may benefit from carnitine supplementation, if recommended by a healthcare provider

Finally, the functional redundancy or compensation between iron metabolic regulators in ferroptosis (e.g., whether inhibition of TFR1 can be rescued by enhanced ferritinophagy) has not been rigorously evaluated, which is essential for designing robust therapeutic strategies targeting iron-dependent ferroptosis